#5655 NEUTROPHIL TO LYMPHOCYTE RATIO, TOTAL IRON BINDING CAPACITY, SERUM ALBUMIN AND SYSTEMIC INFLAMMATION IN CHILDREN WITH CHRONIC KIDNEY DISEASE

Abstract Background and Aims Chronic kidney disease (CKD) is widely linked to chronic inflammation, with a higher incidence in the advanced stages of disease. Recognition systemic inflammation may be useful for prompt diagnosis management various CKD related disorders open door towards development application anti-inflammatory strategy treatments. This case-control cross-sectional study investigates association neutrophil lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), total iron binding capacity (TIBC) serum albumin high interleukin-6 (IL-6) children (CKD). Method NLR PLR were measured 53 patients (median age: 12.9 years) 25 healthy controls, stratified by age sex. Lipid profile, glucose tolerance parameters, albumin, uric acid IL-6 patient group. Results Compared (p = 0.004 p 0.032 respectively), particularly those on dialysis (CKD 5D) (17 patients) (p<0.001 0.001). LnIL-6 was correlated (rs 0.344, 0.014), -0.350, 0.011) TIBC -0.345, 0.012) after adjustment stage, while correlation between lnIL-6 not significant 0.206, 0.151). Patients ≥1.7, ≤300 μg/dl ≤3.8 g/dl presented risk increased (15 regardless stage (OR 5.499, 95% CI 1.272-22.017, 0.016, OR 9.818, 2.311-41.706, 0.002 7.543, 1.891-30.083, 0.004). ≥1.7 TIBC≤ 300 predicted highest sensitivity (73.3%), ≤ 3.8 specificity (97.4%). Conclusion Both increase pediatric CKD, especially 5D. rather than serve as diagnostic marker along albumin.